Glenn Gaesser is an expert in the impact of exercise, diet and cardiovascular health. Gaesser's work has included exercise training interventions, muscular efficiency, and oxygen uptake during and after exercise. He's an advocate of breaking long periods of stagnance with physical activity. He speaks on the notion of health at any size, supporting a non-weight-loss-centered approach to treating obesity-related health issues. Metabolic efficiency and dietary habits are a major part of his work.

Gaesser is the center director for the College of Health Solution and a professor of Exercise Physiology.

He has served as the Southwest Chapter of the American College of Sports Medicine. He has also worked with the Center for Disease Control and has collaborated with NASA as well.